Erratum: Mouse Small eye results from mutation in a paired-like homebox-containing gene
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چکیده
منابع مشابه
A new missense mutation in the paired domain of the mouse Pax3 gene
Mice with dominant white spotting occurred spontaneously in the C3.NSY-(D11Mit74-D11Mit229) strain. Linkage analysis indicated that the locus for white spotting was located in the vicinity of the Pax3 gene on chromosome 1. Crosses of white-spotted mice showed that homozygosity for the mutation caused tail and limb abnormalities and embryonic lethality as a result of exencephaly; these phenotype...
متن کاملMutation in a novel connexin-like gene (Gjf1) in the mouse affects early lens development and causes a variable small-eye phenotype.
PURPOSE The purpose of the study was the characterization of the novel small-eye mutant Aey12 in the mouse. METHODS The eyes of the mutants were described morphologically and histologically and by in situ hybridization. RESULTS The homozygotes were viable and fully fertile, which identifies Aey12 as a new microphthalmia phenotype in the mouse, different from Maf or Pax6 mutants. Histologic ...
متن کاملDmbx1, a novel evolutionarily conserved paired-like homeobox gene expressed in the brain of mouse embryos
To identify novel homeobox genes expressed during mouse embryogenesis, we searched the databases and found a novel mouse paired-like homeobox gene, Dmbx1(diencephalon/mesencephalon-expressed brain homeobox gene 1), that is also conserved in zebrafish and human. Linkage analysis mapped mouse Dmbx1 to the mid-portion of chromosome 4 that is the homologous gene cluster region of human chromosome 1...
متن کاملNovel small-eye allele in paired box gene 6 (Pax6) is caused by a point mutation in intron 7 and creates a new exon
PURPOSE Within a mutagenesis screen, we identified the new mouse mutant Aey80 with small eyes; homozygous mutants were not obtained. The aim of the study was its molecular characterization. METHODS We analyzed the offspring of paternally N-ethyl-N-nitrosourea (ENU)-treated C3HeB/FeJ mice for dysmorphology parameters, which can be observed with the naked eye. The Aey80 mutant (abnormality of t...
متن کاملAAV-Mediated Gene Therapy for Retinal Degeneration in the rd10 Mouse Containing a Recessive PDEβ Mutation
METHODS. One eye of a cohort of rd10 mice kept in a dark environment was subretinally injected at postnatal day (P) 14 with 1 L AAV5-smCBA-PDE . The contralateral eye was not injected. The animals were then maintained for 2 weeks in the dark before they were moved to a normal 12-hour light/12hour dark cycling light environment for visually guided behavioral training. Three weeks after injection...
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ژورنال
عنوان ژورنال: Nature
سال: 1992
ISSN: 0028-0836,1476-4687
DOI: 10.1038/355750a0